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A hand-crafted list of notable publications and news in the field of nuclear medicine and theranostics.

• Evaluating the Utility of ¹⁸F-FDG PET/CT in Cancer of Unknown Primary

  ¹⁸F-FDG PET/CT plays a complementary role in CUP diagnostic work-up and was able to determine the likely primary site in 41% of cases. OS is improved with primary site identification, demonstrating the value of access to diagnostic ¹⁸F-FDG PET/CT for CUP patients.
  jnm.snmjournals.org

• The LUTADOSE trial: tumour dosimetry after the first administration predicts PFS in GEP NET patients treated with ¹⁷⁷Lu-DOTATATE

  Patients with a mean tumour absorbed dose lower than the best cut-off value of 10.6 Gy after first cycle had a significantly shorter median PFS (HR 8.6, 95% CI: 2–37).
  link.springer.com

• Prognostic significance of a negative PSMA PET/CT in biochemical recurrence of prostate cancer

  Salvage RT is associated with delayed clinical progression in patients with post radical prostatectomy biochemical recurrence and negative PSMA PET/CT (HR: 0.2, p=0.03). Median follow-up was 39 months.
  pubmed.ncbi.nlm.nih.gov

• Emission of internal conversion electrons rather than Auger electrons increased the nucleus-absorbed dose for ¹⁶¹Tb compared with ¹⁷⁷Lu

  ¹⁶¹Tb-labeled DOTATATE and DOTA-LM3 delivered 3.6 and 3.8 times higher doses to the cell nucleus, respectively, than their ¹⁷⁷Lu-labeled counterparts. This increased nucleus-absorbed dose was mainly due to the additional emission of IC and not Auger electrons by ¹⁶¹Tb.
  jnm.snmjournals.org