Dedifferentiation in prostate cancer

Case submitted by Nazim Coskun

68-year-old male

Prostate adenocarcinoma

Gleason 5+4

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  • Selected slices showing increased PSMA expression in multiple bone metastases.
  • Multiple hypodense lesions in liver did not show PSMA expression.

Patient underwent 18F-FDG PET/CT and 68Ga-DOTA-TATE PET/CT for the characterization of liver lesions.

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Multiple liver lesions did not demonstrate 68Ga-DOTA-TATE uptake.

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Selected slices showing increased 18F-FDG uptake in liver metastases.

Case Notes

Liver metastases in prostate cancer are usually associated with dedifferentiation and high-grade cancers, leading to loss of PSMA expression .

Updated on Dec 22, 2023